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From single molecules to dynamic systems

PUBLISHED WORK

NOISE MINIMIZATION IN CELL-FREE GENE EXPRESSION

M.W. Bartelds, Ó. García-Blay, P.G.A. Verhagen, E.J. Wubbolts, B. van Sluijs, H.A. Heus, T.F.A. de Greef, W.T.S. Huck, M.M.K. Hansen (2023)

ACS Synthetic Biology 8: 2217–2225

TASOR EPIGENETIC REPRESSOR COOPERATES WITH A CNOT1 RNA DEGRADATION PATHWAY TO REPRESS HIV

R. Matkovic, M. Morel, S. Lanciano, P. Larrous, B. Martin, F. Bejjani, V. Vauthier, M.M.K Hansen, S. Emiliani, G. Cristofari, S. Gallois-Montbrun, F. Margottin-Goguet (2022)

Nature Communications 13: 66

A DNA-REPAIR PATHWAY CAN AFFECT TRANSCRIPTIONAL NOISE TO PROMOTE CELL FATE TRANSITIONS

R.V. Desai, X. Chen, B. Martin, S. Chaturvedi, D. W. Hwang, W. Li, C. Yu, S. Ding, M. Thomson, R.H. Singer, R.A. Coleman, M.M.K Hansen, L.S. Weinberger (2021)

Science 373: eabc6506

TRANSCRIPTION AND TRANSLATION IN CYTOMIMETIC PROTOCELLS PERFORM MOST EFFICIENTLY AT DISTINCT MACROMOLECULAR CROWDING CONDITIONS

M.A. Vibhute, M.H. Schaap, R.J.M. Maas, F.H.T. Nelissen, E.Spruijt, H.A. Heus, M.M.K. Hansen*, W.T.S. Huck*

(2020) *Co-corresponding authors

ACS Synthetic Biology 9: 2797–2807

POST-TRANSCRIPTIONAL NOISE CONTROL

M.M.K. Hansen* and L.S. Weinberger* (2019) *Co-corresponding authors

BioEsays 41: 1900044

CYTOPLASMIC AMPLIFICATION OF TRANSCRIPTIONAL NOISE GENERATES SUBSTANTIAL CELL-TO-CELL VARIABILITY

M.M.K. Hansen, R.V. Desai, M.L. Simpson, L.S. Weinberger. (2018)

Cell Systems 7: 384-397. [OA]

A POST-TRANSCRIPTIONAL FEEDBACK MECHANISM FOR NOISE SUPPRESSION AND FATE STABILIZATION

M.M.K. Hansen*, W.Y. Wen*, E. Ingerman*, B.S. Razooky, Cassandra E. Thompson, R.D. Dar, C. Chin, M.L. Simpson, L.S. Weinberger. (2018)

Cell 173: 1609-1621 *Authors contributed equally

NONLATCHING POSITIVE FEEDBACK ENABLES ROBUST BIMODALITY BY DECOUPLING EXPRESSION NOISE FROM THE MEAN

B.S Razooky, Y. Cao, M.M.K. Hansen, A.S. Perelson, M.L. Simpson, L.S. Weinberger. (2017)

PLoS Biol., 15: e2000841.

PROTEIN SYNTHESIS IN COUPLED AND UNCOUPLED CELL-FREE PROKARYOTIC GENE EXPRESSION SYSTEM

M.M.K. Hansen, M. Ventosa Rosquelles, M. Yellesarapu, R.J.M. Maas, A.J. van Vugt-Jonker, H.A. Heus and W.T.S. Huck. (2016)

ACS Synth. Biol., 5: 1443-1440.

MACROMOLECULAR CROWDING CREATES HETEROGENEOUS ENVIRONMENTS OF GENE EXPRESSION IN PICOLITRE DROPLETS

M.M.K. Hansen, L.H.H. Meijer, E. Spruijt, R.J.M. Maas, M. Ventosa Rosquelles, J. Groen, H.A. Heus, W.T.S. Huck. (2016)

Nat. Nanotechnol., 11: 191-197.

CELL-LIKE NANOSTRUCTURED ENVIRONMENTS ALTER DIFFUSION AND REACTION KINETICS IN CELL-FREE GENE EXPRESSION

M.M.K. Hansen, S. Pfaffenholz, D. Foschenpoth, H.A. Heus, J. Thiele, W.T.S. Huck. (2016)

ChemBioChem 17: 228-232.

DNA-FUNCTIONALIZED HYDROGELS FOR CONFINED MEMBRANE-FREE IN VITRO TRANSCRIPTION/TRANSLATION

J. Thiele, Y. Ma, D. Foschepoth, M.M.K. Hansen, C. Steffen, H.A. Heus, W.T.S. Huck. (2014)
Lab Chip 14: 2651-2656.

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